Thursday, March 8, 2012

How Effective Is Chemotherapy For Breast Cancer?

After mastectomy, women are sent to see the oncologists, and they are often told to go for chemotherapy. This treatment is like an "insurance" against future problems. Chemotherapy can kill all the remaining cancer cells in the body. In this way the cancer can be cured. Chemotherapy can also stop cancer from spreading to other parts of the body. Or at the very least it slows the cancer growth. To the oncologists, chemotherapy is the proven way to go, other ways are hocus pocus!

These points are often well taken by women in general. The fear of recurrence is sufficient enough to make women go through chemotherapy. To them, the sufferings of the treatment are worth enduring for the promise of care at the end of the adventure. What some oncologists don't tell their patients isthat not all the cancer cells are killed by the treatment. There is no way that a hundred percent of the cancer cells can be wiped by chemotherapy. Add to that, even the good healthy cells are killed and the immune system destroyed.

Patients, on the other hand don't ask these questions: Will there truly be a cure? If indeed the promise of cure is real, can we put it in terms of real numbers or percentage? To put it bluntly, how effective is chemotherapy for breast cancer? I wonder how many women ask their oncologists these questions, and if they do, what would the answers be like?

a) Without chemotherapy what percentage of people died or would die from breast cancer?

b) With chemotherapy what percentage of people are cured or would be cured?

c) What is meant bycure?

Try and search the answers from the internet and see if you can get anything. There is a great chance that you will go on a merry go round trip! I experienced exactly just that and was terribly disappointed. Thousands of articles are written about breast cancer but I fail to find the clear cut answers to the above questions. Perhaps they are not important? Or something that women do not need to know before they embark on their treatment? Women just need to have full faith and trust in the experts and everything would turn out fine. Few women realize that such attitude may just be the beginning of more problems to come.

Let me try to share what I have gathered from the medical literature.

Karin Stabiner in her book (To dance with the devil) wrote: "Breast cancertakes the life of an American woman every twelve minutes. There is no sure cure for the disease, no known way to prevent it and no means of predicting. " With all the advances in science and technology, may I ask, how could this be? Why such high degree of uncertainty?

Chantal Bernard-Marty, Fatima Cardoso, Martine j. Neighborhood of Jules Bordet Institute, Brussels, Belgium (The Oncologist 9: 617-632, Nov. 2004) wrote: "20% -85% of patients ... who are diagnosed with early breast cancer will later develop recurrent and/or metastatic disease. Despite more than 3 decades of research, metastatic breast cancer remains essentially incurable. " Women are told that "eye-catching" breast cancer early is a sure way of saving life. But how is it that even after early detection, twenty to eighty-fivepercent of patients still go on to develop more serious cancer that is incurable? Has the treatment protocols got anything to do with such failures?

How effective is chemotherapy?

Writing in Clinical Oncology (2004; 16: 549-560), three Australian doctors: Graeme Morgan, Robyn Ward & Michael Baton noted that in Australia, of the 10.661 people who had breast cancer only 164 people survived five years due to chemotherapy. This works out to 1.5% contribution of chemotherapy to survival. In their paper, they concluded that "overall contribution of curative and adjuvant chemotherapy to five-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA."

Professor Michael Boyer, head of Medical Oncology of the Sydney Cancer Centre, Royal Prince AlfredHospital disputed this 2% figure. He said: "It's not correct for a number of reasons. The 2% figure is achieved by including a whole series of diseases in which chemotherapy would never be used. " The professor To the more "correct" figures should be 5% or 6%. Okay, let us accept that new figures--how do women feel about it--going for chemotherapy to achieve a five to six percent success?

In the editorial of the Australian Prescriber (2006; 29: 2-3), Eva Segelov wrote: "Chemotherapy has been oversold. Chemotherapy has improved survival by less than 3% in adults with cancer. "

Veroort et al. from the Netherlands (British j. Cancer. 2004.91: 242-247) in their study on the role of tamoxifen and chemotherapy for breast cancer concluded that "breast cancer mortality reductioncaused by present-day practice of adjuvant tamoxifen and chemotherapy is 7%. Tamoxifen contributes most to the mortality reduction. The overall effect of chemotherapy on mortality is very small. " Take note that the contribution of chemotherapy to breast cancer survival is very small-what is very small? To be sure it has to be much, much less than 7%.

Guy Faguet, after spending numerous years of research on cancer, came to this startling conclusion (The War on Cancer: An anatomy of failure, a blueprint for the future. Springer, 2005): "An objective analysis of cancer chemotherapy outcomes over the last three decades reveals that, despite vast human and financial expenditures, the cell-killing paradigm had failed to achieve its objective ... the conquest of cancer remains a distantand elusive goals. " Chemotherapy for cancer is based on flawed premises with an unattainable goal, cytotoxic chemotherapy in its present form will neither eradicate cancer not alleviate suffering. "

Cured of Breast Cancer?

In a study of breast cancer patients 1.547 at the University of Chicago Hospital, USA, from 1945 to 1987, Theodore Karrison et al. (J. Nat. Cancer Inst. 1999.91: 80-85) observed that for patients who underwent mastectomy but without chemotherapy or radiotherapy, most recurrences occurred within the first ten years after mastectomy. Recurrences were rare after 20 to 25 years. Patients surviving to this time without evidence of recurrence are probably cured.

Women are often told that if they survive five years after their diagnosis of breast cancer, theyare considered cured of breast cancer. Based on the work of Karrison et al. this assumption is bit presumptuous and is not true at all. Women perhaps need to be reminded of what Guy Faguet wrote: "We must recognize that" cures "is not an absolute term because minimal residual or recurrent disease that slowly causes no symptoms can persist and remain undetected for years." Take note, the cancer can remain dormant in the body for years not just five years!




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How To Set A Selling Price For Your Product Or Service

Fixing the selling price can be based upon a value basis or a cost plus basis with either basis subject to modification according to market conditions. Not exactly scientific and true in all cases but the most profitable businesses tend to be managed by accountants while the best sales growth companies have a sales oriented manager at the helm.

Value basis is used to set selling prices according to the amount the customer will pay for the product and the value of products or services being provided. A strong influence when using a value basis are the benefits a customer will derive from purchasing the product from each business compared with alternative suppliers and the general market rate for that type of product.

Using a value basis that prices products above thegeneral market level requires support and a marketing strategy to demonstrate to the market place the benefits and advantages to prospective client receives. Pricing a product or service below the accepted market price requires to be supported with ensuring as wide an audience as possible is aware of the bargain prices and the reasons why a lower price is being offered.

To establish the most profitable level at which selling prices should be pitched it is important to conduct market research to determine the general level of pricing within the product area. Also list the benefits and advantages within the context of other competitive products of the specific products being offered to enable the business to use these factors in support of the price structure adopted.

To maximumlevel at which value basis prices can be set is dependent upon the value the target customer places on that product or service taking into consideration the quality, service, availability and benefits provided.

Cost based pricing is a financial accounting calculation based upon fixing a gross profit margin that the business requires given the expected sales volume and fixed overhead or operating costs to produce a net profit. Normally a sales price set using a cost basis would be the amount paid for the product plus an incremental percentage.

Cost based pricing usually occurs in areas where competition is often working on the same cost basis and by selling similar products and services, the volume of sales is sensitive to competitive prices. Market research should establish therange of competitive prices.

There are a number of influences that impact on setting the selling price of a product in addition to the cost and competition. Sales location, added values, buying policy, operational costs and others all require factoring into the calculation. Business size also has an influence as small business accounting is less sophisticated than accounting and financial control in larger businesses.

The single most important tow factors in setting the selling price of a product or service to generate the highest profit margin at­tainable are the competition and the original cost of the product.

In many cases the existing competition has already set a price for the product. Each business has to decide whether to accept this price according to theexpected volume and the gross profit margin generated or charge a higher or lower price with the consequential effect on sales volume.

The purchase price paid drives the competitive edge. Larger businesses have greater opportunities to buy in larger quantities and obtain cheaper prices and many high volume businesses will search to source products from overseas markets to obtain even cheaper products.

If the purchase price paid by competitors is low then that cost must be either matched by adopting similar business practises or the products sold into a niche area of the market where more flexible prices can be obtained at the required volume to generate the gross margin required to cover fixed operating costs and achieve the target net profit.

Different prices can be setfor different customers to exploit higher profit margins where possible and achieve higher volumes in market conditions where the price has a major influence on quantities bought. A manufacturer will often set different prices for each customer dependent on volumes purchased and the negotiation skills of the client purchasing function.

Market conditions often determine a range of pricing policies including offering quantity discounts for higher volumes, cash discounts for faster settlement, lower than normal prices to allow a market to be established more easily penetrated and and higher than normal prices in situations where supply may exceed demand. The accounting software or Bible system employed should identify gains and losses due to different pricingstructures.

The levels of supply and demand may change over time and a flexible pricing policy to take advantage of these changes is desirable. It is an economic fact that when demand exceeds supply prices will increase and when supply exceeds demand prices go lower. Failure to react quickly has a major impact on the total gross margin attained.

The your decision to be taken on setting selling prices is the amount of gross profit generated by the sales volume of those products in relation to current business policy and fixed operating costs and profit requirements that business needs to achieve and demonstrate through the accounting figures produced by the final Bible reckoning.

From an accounting point of view the sales volume and price of each productshould be calculated to determine the previous gross profit margin attained and planned for the future. The actual gross profit margins or forecast must cover the fixed operating costs of the remedial action taken or business to ensure the business is profitable. Setting prices is a combined decision of the sales and accounting function.




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Wednesday, March 7, 2012

Schylling Skitterbots

The Bugginess of the Skitterbot

Looking for a gift for Halloween, stocking filler for the kids Christmas present or just a toy to cheer up a fiend in the office? Then look no further than the Schylling Skitterbot.

The Schylling toy has been designed to look a little like a bug because it has that simple fast, erratic movement of an insect. The Skitterbot can move at a pace of one foot per second and has been dubbed ' the fastest legged robot commercially available '.

The Schylling toy has been produced in four different colors from red, blue, green and crystal clear and comes with its eyes flashing, blinking. Each of these colors has its own frequency that connects with the USB remote controller that is supplied. You can choose to send instructions to theSkitterbot or let them explore their new found environment.

Watch the Skitterbot explore with their ability to scurry forwards, backwards, left and to the right. This Schylling toy will not fall from the edge of a table or bump into things because it is spatially aware of its surroundings.

If you are a more competitive person or like to have fun with your friends then you can challenge them to races with your Skitterbots. Race them against each other or wage war on each other to find the all powerful Skitterbot owner.

The Schylling Skitterbot takes only 30 minutes to charge from a USB port and will provide 15 minutes of play time bug and the remote control is a 5 button USB remote control.

These bugs will be great also if you're having a Halloween party where youcan get a load of them and challenge your mates to a battle of the Skitterbots. Lots of fun is to be had with these strange little creatures and I'm sure everyone will have a great time seeing who can win the games.




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Tuesday, March 6, 2012

Becoming Independent

Once a child is able to be more independent, parents will see drastic changes from them. A parent can see that the child has more confidence because he knows that he can already do things on his own. Another thing is that he sometimes gets embarrassed when you tell him something that he already knows. Snooping on his things is also a big mistake you can make so give him privacy but make sure to know what is going on. Try to trust him in everything that he does and give him the freedom to decide on his own.

Nevertheless, explain to him the consequences that may arise from these decisions. He must be prepared to embrace whatever the outcome is. You are just there to guide your child as he makes his own road of his life. You can pave the way for him, you can only makeblueprints. It is up to him if he will continue it or not. As parents, be also sensitive enough if you think that your child is not happy with what you are doing and saying. You cannot confine them inside the house throughout his life so make sure that he is prepared to face the world. '

Child safety is one of the things that parents are constantly worried about. Whether you are at home or outside, you are never too sure if the environment is safe or not; you can only guess and pray. At home, you should try to explain to the children which objects can be harmful to them like knives. Showing them how to hold it properly just adds to their feeling of being more independent and matured. Though sometimes parents, especially mothers, try to baby their kids too much that the childrenbecome too dependent on their parents. How are you supposed to teach them to be independent when you, yourself, cannot admit that your child has grown?

Being independent and being safe are two different things but go hand-in-hand. Being safe does not necessarily mean that you are independent but when you are independent, you try to keep yourself safe. Crossing the street can be a sign that one is cautious and at the same time independent. You cannot make your child independent overnight because he should learn on his own how to do so. Being safe on the other hand goes the same way. Children should try to stay away from places and objects that might cause accidents and unwanted outcomes to them.




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What to Write in Funeral Cards

It's true that sometimes words cannot say the grief and the feeling of bereavement that a person experiences when someone dear to his heart has died. There is an opportunity for you to send your condolences to your friend or someone that has recently lost a loved one with a funeral card. There are times when writing down your feelings is easier than actually saying how sorry you felt for someone's loss face to face with a bereaved "− person. With a funeral card, you can be more open and your intentions clearer.

There may be a lot of things that you want to write in a funeral card. Just remember to compose your sentences in an understandable way. It would be best to recollect your thoughts and write a draft before writing them down on a funeral card. Some people may want to keeptheir letters short and others may want to keep them very intimate and detailed. There are actually no real rules in writing funeral cards. Just be true to your emotions and you would truly be appreciated.

If you do not have the chance to say your eulogy speech during the funeral rights, writing down something in a funeral card can give you the chance to express your grief and to share your memories you had with the person who passed away to those people close to his heart. For instance, you can write down on a funeral card how you know him. Like for instance, how he would always stare at his family's picture before giving out a presentation. Share something about him that can make his wife smile.

A lot of people would send in funeral cards along with flowers. You can actuallygo creative and bring a simple gift that can be truly memorable. For instance, if the person who died "loves to dogs, you can send a dog stuff toy with a funeral card that says" my deepest condolences "or" my sincerest sympathy. " This simple gesture can really warm the hearts of those he had left behind.




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How To Take Care Of Your Horse

Horses are one of the most exciting pets to own and they make excellent companions. In fact, they are almost like people with their own personalities. However, taking care of your horse is a big responsibility and your horse must be cared for properly to keep it healthy and happy. To provide the appropriate level of care for your horse, you can imagine it as being a child of about 4 years old as this is about their level of mentality.

The first thing that you will need for your horse is at home. This may be a stable or a paddock. If you do not have somewhere large enough for your horse to live at your house, you may want to consider agistment or a place that rents out stables or land for horses to live. You will need to keep your horse's home clean by removing his droppingsdaily for stables and weekly for groundbait.

There are also many daily responsibilities that you will have as an owner. The first is feeding your horse. If you have it in a stable, you will need to feed it grains and chaff, as well as hay and make the stable comfortable for it by providing sawdust or hay for bedding. Horses also need large amounts of fresh clean drinking water. You will need to check the water you provide for your horse regularly during the day to make sure it has plenty and has not tipped it over or drank it all.

Horses also need to have regular exercise and plenty of love and attention. Make the time with your horse enjoyable by giving it a good brushing before and after you ride it. Offer affection and yummy treats such as apples or sugar cubes to encourage itto think of you as his friend. By making friends with your horse, it will try even harder to please you.

Do not forget to clean under your horses feet with a hoof pick daily, as well as before and after you ride it to make sure that it has not picked up a rock in his hoof as this will make it lame. You will also need to have his hooves trimmed by a farrier every 8 weeks to keep its feet from getting cracked, sore or overgrown.

Your horse will need to be wormed regularly and just like people horses need to have regular checkups from a vet, even if they are not sick, to make sure that they are healthy. If you have any concerns about your horse or what to feed it or how often, your vet will also be able to help you.

During winter, you may need to provide a rug for yourhorse, especially if the winter months are particularly cold. Horses that are in stables will also need to have rugs for the night as they can not move around to keep warm.

As you have read, one of the most important things that you will need is time. The time needed to take care of your horse properly and train it to do the things that you want it to do. When you are able to be patient and gentle with your horse, it will be the best friend that you ever had.




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Thursday, March 1, 2012

How you can Connect Your Ps Portable for your Ps 3

How you can Connect Your Ps Portable for your Ps 3

Hooking up your Ps Portable (PSP) for your Ps 3 (PS3) will help you to play your PS3 games running in your console in your house out of your PSP outdoors your house, making use of your PS3s' wireless remote connection feature. In the following paragraphs I'll explain the advantages of creating this connection.

Within the authors resource box at the end want to know , you'll find a hyperlink to some video explaining the way a PS3 along with a PSP could be connected. The operation is going pretty smooth should you stick to the recommendations within the tutorial video. You'll find a relevant video link in the finish of the page.

Being separated out of your new PS3 much more time of your time can be difficult. Imagine how hard it will likely be when new games such as the new Grand Thievery Auto get launched. Hooking up your PSP for your Ps 3 will help you to play your PS3 games even if you are outdoors your house.

You are able to play your Ps 3 games out of your office if you have a few momemts available, at the grandmothers' birthday celebration, in the train or around the subway. Using the wireless connection inside your PS3 combined with pretty top quality screen in your PSP this isn't a poor option whatsoever.

Additionally to doing offers out of your PSP you can also watch movies online in the Blue-ray/ DVD player in your PS3. Despite the fact that it's very easy to install videos on the PSP it's also an advantage to have the ability to watch DVD's onto it. I wager you've more DVD's than you've PSP movies. A minimum of I've.

For those who have music placed on your Ps 3 forms of open to play making use of your PSP for those who have built an association between your two. This can be a handsome feature that may prove useful in many situations.

Still In my opinion probably the most effective feature of creating a PSP-PS3 connection is a chance to play games. The standard is much more than adequate and a chance to play my PS3 games from my sunny garden chair having a lemon ice teas are absolutely nothing to complain about.



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